The neurotoxicity of ethylcholine mustard aziridinium (ECMA) in rat brain reaggregate cultures
Related Experiment Video
Updated: Jul 27, 2026
15:05
Functional Evaluation of Biological Neurotoxins in Networked Cultures of Stem Cell-derived Central Nervous System Neurons
Published on: February 5, 2015
A M Pillar1, A K Prince, C K Atterwill
1Department of Pharmacology, King's College (KQC), Strand, London, U.K.
Toxicology
|April 1, 1988
Abstract:
The cholinergic neurotoxin ECMA causes a biphasic loss of choline acetyltransferase activity in foetal rat whole brain reaggregate cultures. Initial direct inhibition is followed by longer-term loss of cholinergic neurones. Final muscarinic receptor binding, neurofilament protein and Na+, K+-ATPase concentrations suggest that the lesion is specific for cholinergic neurones at 12.5 microM ECMA, but is more generalised at 50 microM ECMA.
