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08:31
Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro
Published on: November 26, 2018
Ageing adversely affects the migration and function of marginal zone B cells
Vivian M Turner1, Neil A Mabbott1
1The Roslin Institute and Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Midlothian, UK.
Immunology
|April 4, 2017
Summary
Aging impairs marginal zone (MZ) B cell function in mice, affecting antigen capture and immune responses. These changes in aged mice highlight risks for elderly individuals against infections like Streptococcus pneumoniae.
Area of Science:
- Immunology
- Aging Research
- Cell Biology
Background:
- Marginal zone (MZ) B cells in the spleen capture blood-borne antigens.
- These cells are crucial for T-cell-independent antibody responses.
- Aging affects immune cell function and susceptibility to infections.
Purpose of the Study:
- To investigate the impact of aging on MZ B cell function in mice.
- To determine the mechanisms behind impaired MZ B cell activity in aged individuals.
- To understand the implications for immunity in the elderly.
Main Methods:
- Analysis of MZ B cell antigen capture and migration in aged mice.
- Use of bone marrow chimeras to differentiate intrinsic vs. extrinsic aging effects.
- Assessment of immunoglobulin production in response to T-cell-independent antigens.
Main Results:
- Antigen capture and follicular shuttling by MZ B cells were impaired in aged mice.
- Aged MZ B cells showed increased migration towards chemoattractants, suggesting retention.
- Impaired MZ B cell function was linked to splenic stromal cells, not intrinsic B cell aging.
- Antibody production in response to TI antigens was reduced in aged mice.
Conclusions:
- Aging negatively impacts MZ B cell function and immune responses.
- Splenic stromal cell aging contributes to impaired MZ B cell follicular shuttling.
- These findings have implications for increased susceptibility to infections in the elderly.
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