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Related Experiment Video

Updated: Jul 9, 2026

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

Recent advances in gut immunology.

N Powell¹, T T MacDonald²

¹Division of Transplantation Immunology and Mucosal Biology, Department of Experimental Immunobiology, Kings College London, London, UK.

Parasite Immunology

|April 4, 2017

Summary

Recent advances reveal complex interactions within the gut's mucosal immune system. Understanding these relationships between immune cells, the gut lining, and microbes is key to maintaining health and preventing disease.

Keywords:

Innate immunity Mucosal immunity adaptive immunity

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Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches

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Last Updated: Jul 9, 2026

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

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Published on: September 18, 2016

In Vivo Photolabeling of Cells in the Colon to Assess Migratory Potential of Hematopoietic Cells in Neonatal Mice

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Published on: August 10, 2018

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches

Published on: November 21, 2018

Area of Science:

Immunology
Gastroenterology
Microbiology

Background:

The mucosal immune system, particularly in the gut, is crucial for maintaining host health.
Recent discoveries have unveiled new cell types and intricate interactions within this system.
Dysregulation of gut homeostasis is linked to various diseases.

Purpose of the Study:

To review recent advances in understanding the mucosal immune system.
To highlight the roles of key immune cells like innate lymphoid cells (ILCs), mucosa-associated invariant T cells (MAIT cells), and mononuclear phagocyte system (MPS) cells.
To explore the interactions between these immune cells, the intestinal epithelium, and the gut microbiota.

Main Methods:

Review of recent scientific literature.
Synthesis of findings on immune cell function and interactions.
Focus on innate lymphoid cells (ILCs), mucosa-associated invariant T cells (MAIT cells), and mononuclear phagocyte system (MPS) cells.

Main Results:

Significant advances in identifying new immune cell types in the gut.
Elucidation of three-way interactions between mucosal immune cells, intestinal epithelium, and microbiota.
Understanding how these interactions maintain gut homeostasis and contribute to disease pathogenesis.

Conclusions:

The intricate crosstalk between immune cells, epithelium, and microbiota is fundamental to gut health.
Dysregulation of these interactions can lead to disease.
Further research into these complex relationships promises to redefine our understanding of intestinal health and disease.