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Roles of AEG-1 in CNS neurons and astrocytes during noncancerous processes
1Department of Neurology and Neuroscience Center, First Hospital of Jilin University, Changchun, People's Republic of China.
Abstract:
Since its initial identification, Astrocyte Elevated Gene-1 (AEG-1) has been recognized as a "star" gene detected in most of the analyzed cancers; AEG-1 can interact with signaling transduction molecules, such as PI3K/Akt and MAPK, to affect the function and viability of cells. Furthermore, its multiple other functions are also gradually being recognized. AEG-1 participates in several biological processes, including embryonic development, glutamate excitotoxicity, inflammation, and endoplasmic reticulum stress. Most of the noncancerous roles of the AEG-1 were identified in studies of the neurological disorders of the CNS. As an oncogene that promotes aberrant cellular processes within the CNS, AEG-1 may also represent an important therapeutic target for the treatment of neurological disease. However, the exact role of the AEG-1 in CNS under normal conditions is still unknown. This review will focus on the literature describing the role of this molecule in CNS neurons and astrocytes during noncancerous processes. © 2017 Wiley Periodicals, Inc.
Insights
Astrocyte Elevated Gene-1 (AEG-1) is a key gene in cancer and neurological disorders. This review explores AEG-1's non-cancerous roles in central nervous system (CNS) neurons and astrocytes.
Area of Science:
- Neuroscience
- Molecular Biology
- Oncology
Background:
- Astrocyte Elevated Gene-1 (AEG-1) is frequently detected in various cancers.
- AEG-1 influences cell function and viability through signaling pathways like PI3K/Akt and MAPK.
- Its roles in embryonic development, excitotoxicity, inflammation, and ER stress are recognized.
Purpose of the Study:
- To review the non-cancerous functions of AEG-1 in the central nervous system (CNS).
- To elucidate the role of AEG-1 in CNS neurons and astrocytes under normal physiological conditions.
- To explore AEG-1 as a potential therapeutic target for neurological diseases.
Main Methods:
- Literature review of studies on AEG-1.
- Analysis of AEG-1's involvement in non-cancerous CNS processes.
- Focus on AEG-1's functions in neurons and astrocytes.
Main Results:
- AEG-1's non-cancerous roles have been primarily identified in the context of neurological disorders.
- AEG-1 acts as an oncogene promoting aberrant cellular processes within the CNS.
- The precise role of AEG-1 in normal CNS function remains largely unknown.
Conclusions:
- AEG-1 is implicated in various biological processes beyond cancer.
- Understanding AEG-1's normal function in the CNS is crucial for neurological disease research.
- AEG-1 presents a potential therapeutic target for CNS disorders.
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