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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

The presence of diastolic and systolic dysfunction in patients with impaired relaxation filling pattern

Balaji Pratap1, Kamala Ramya Kallur1, Edgar Argulian1

  • 1Mt Sinai St. Luke's Hospital, New York, NY, USA.

Echocardiography (Mount Kisco, N.Y.)
|April 4, 2017
PubMed

Insights

Patients with preserved ejection fraction but impaired relaxation show varied systolic and diastolic dysfunction. A comprehensive assessment beyond isolated diastolic dysfunction is crucial for characterizing these heart conditions.

Area of Science:

  • Cardiology
  • Echocardiography
  • Heart Failure

Background:

  • Impaired relaxation filling pattern with preserved ejection fraction is common.
  • This pattern is often attributed to early diastolic dysfunction.
  • The study aimed to identify systolic and diastolic dysfunction markers in these patients.

Purpose of the Study:

  • To determine the distribution of systolic and diastolic dysfunction markers.
  • To analyze echocardiographic parameters in patients with impaired relaxation and preserved ejection fraction.
  • To investigate factors associated with reduced global longitudinal strain.

Main Methods:

  • Retrospective observational study of 106 patients.
  • Diastolic dysfunction assessed using the American Society of Echocardiography "50% rule".
  • Systolic dysfunction evaluated by global longitudinal strain and circumferential strain, with patients grouped by longitudinal strain tertiles.

Main Results:

  • Lower strain group showed higher rates of definite diastolic dysfunction (23% vs 7%) and lower rates of normal diastolic function (54% vs 80%).
  • Patients with lower longitudinal strain also had lower circumferential strain (-21.2% vs -25.7%).
  • Left atrial enlargement, increased left ventricular mass index, and altered E-wave deceleration time were independently associated with lower global longitudinal strain.

Conclusions:

  • Patients with impaired relaxation and preserved ejection fraction exhibit diverse left ventricular systolic and diastolic abnormalities.
  • Relying solely on diastolic dysfunction assessment may not fully capture the complexity of this patient group.
  • Comprehensive evaluation of both systolic and diastolic function is necessary.
Abstract

Keywords:
diastolic dysfunctionimpaired relaxationleft ventricular strain

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