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Emerging Biofabrication Strategies for Engineering Complex Tissue Constructs.

R Daniel Pedde¹, Bahram Mirani¹, Ali Navaei²

¹Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC, V8P 5C2, Canada.

Advanced Materials (Deerfield Beach, Fla.)

|April 4, 2017

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This summary is machine-generated.

Innovative biofabrication techniques like 3D bioprinting and textile methods are advancing tissue engineering. These strategies aim to overcome challenges in creating complex, functional engineered tissues for organ repair and regeneration.

Area of Science:

Regenerative Medicine and Tissue Engineering
Biomaterials Science
Biofabrication Technologies

Background:

Growing demand for organ transplantation and donor scarcity necessitate novel strategies for tissue repair and regeneration.
Bioengineering organs using patient cells, scaffolds, and signals offers a potential solution but faces challenges in replicating native tissue complexity.
Significant advancements in biofabrication have been made to address these limitations over the past decade.

Purpose of the Study:

To review and compare emerging three-dimensional (3D) bioprinting and textile biofabrication techniques.
To outline the use of biomaterials and hybrid scaffolds in tissue engineering.
To discuss critical design considerations for fabricating functional, complex engineered tissues.

Main Methods:

Keywords:

3D printing biofabrication regenerative medicine textiles tissue engineering

Related Experiment Videos

Review of recent literature on advanced biofabrication strategies, focusing on 3D bioprinting and textile techniques.
Comparison of the advantages and disadvantages of different biofabrication approaches.
Analysis of biomaterial choices, scaffold design, and key fabrication parameters (structural, physical, biological, economical).

Main Results:

Emerging 3D bioprinting and textile techniques show promise for overcoming challenges in tissue complexity.
Various biomaterials and hybrid scaffolds are being utilized, with specific design considerations crucial for success.
These biofabrication strategies have demonstrated potential applications in neural, skin, connective, and muscle tissue engineering.

Conclusions:

Biofabrication, particularly through 3D bioprinting and textile methods, is a rapidly advancing field crucial for addressing organ shortages.
Careful consideration of materials, scaffolds, and design parameters is essential for creating functional engineered tissues.
These techniques hold significant promise for future clinical applications in regenerative medicine.