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Diterpenes and Their Derivatives as Potential Anticancer Agents
1Department of Pharmacy, Southern University Bangladesh, Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, 64.049-550, Brazil.
Phytotherapy Research : PTR
|April 4, 2017
Summary
Diterpenes show significant potential as anticancer agents. This review highlights over 250 anticancer diterpenes and their derivatives, with some progressing through clinical trials for cancer treatment.
Area of Science:
- Medicinal Chemistry
- Pharmacology
- Natural Products
Background:
- Diterpenes and their derivatives are recognized for their significant biological activities.
- These compounds have garnered substantial interest as potential therapeutic agents.
Purpose of the Study:
- To review and consolidate information on anticancer diterpenes.
- To identify and analyze diterpenes with demonstrated anticancer properties.
Main Methods:
- A comprehensive literature search was conducted across multiple scientific databases (PubMed, Science Direct, Web of Science, Scopus, ACS).
- The search covered articles published between January 2012 and January 2017, using selected keywords.
- A total of 28,789 articles were initially identified, with 240 ultimately included in the review.
Main Results:
- Over 250 anticancer diterpenes and their derivatives were identified.
- These compounds exhibit diverse mechanisms of action across various cellular pathways.
- Some identified diterpenes are currently undergoing clinical, nonclinical, or preclinical trials.
Conclusions:
- Diterpenes represent a promising class of molecules for cancer therapy.
- Further research and development of diterpenes could lead to novel cancer treatments.