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Annulative π-Extension (APEX): Rapid Access to Fused Arenes, Heteroarenes, and Nanographenes
Hideto Ito1, Kyohei Ozaki1, Kenichiro Itami1,2
1Graduate School of Science, Nagoya University, Chikusa, Nagoya, 464-8602, Japan.
Abstract:
The annulative π-extension (APEX) reaction has the potential to have a tremendous impact on the fields of materials science and bioimaging, as well as on the pharmaceutical/agrochemical industries, since it allows access to fused aromatic systems from relatively simple aromatic compounds in a single step. Typically, an APEX reaction facilitates a one-pot π-extension without the need to prefunctionalize the aromatic compounds. This advantageous feature is extremely useful for tuning and modifying molecular properties in the last step of a synthesis. In this Review, the progress and applications of APEX reactions of unfunctionalized arenes and heteroarenes are described.
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