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Related Experiment Videos

A self-deploying drug release device using polymeric films.

Taro Kondo1, Zhaleh Kashkouli Nezhad2, Jin Suzuki1

  • 1Department of Finemechanics, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|April 4, 2017
PubMed
Summary

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This study introduces a novel self-deploying sheet device for sustained protein drug delivery. The flexible device, made from PEGDM and collagen microparticles, unfolds in water for minimally invasive transplantation.

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Regenerative Medicine

Background:

  • Developing advanced drug delivery systems is crucial for effective therapeutic outcomes.
  • Minimally invasive transplantation methods are needed for treating diseased tissues and organs.
  • Controlling drug release kinetics and ensuring device stability are key challenges.

Purpose of the Study:

  • To develop a novel sheet-type device for self-deployment and sustained protein drug release.
  • To investigate the role of collagen microparticles in drug permeability and release.
  • To evaluate the device's structural integrity, self-unfolding mechanism, and injectability.

Main Methods:

  • Fabrication of a photopolymerized polyethylene glycol dimethacrylate (PEGDM) sheet with embedded collagen microparticles (COLs).
Keywords:
drug delivery systeminjectableself-deploymentsheet-type device

Related Experiment Videos

  • Characterization of drug permeability and sustained release properties based on COL density and electrostatic interactions.
  • Assessment of the device's flexibility, structural stability via van der Waals forces, and self-deployment mechanism in aqueous environments.
  • Evaluation of injectability through a conventional syringe needle.

    • Main Results:

    • Increased collagen microparticle density enhanced drug permeability.
    • Electrostatic interactions between protein drugs and collagen microparticles enabled prolonged sustained release.
    • The PEGDM/COLs device demonstrated flexibility, structural integrity maintained by van der Waals forces, and self-unfolding upon immersion in water.
    • The rolled-up device was successfully injected via a syringe needle, recovering its original shape.

    Conclusions:

    • The developed sheet-type device offers a promising platform for self-deployment and sustained protein drug delivery.
    • Its ability to unfold and be delivered minimally invasively presents potential for improved therapeutic outcomes and reduced side effects.
    • This technology could advance treatments for various diseases affecting tissues and organs.