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New Cytotoxic Alkylated Chalcones from Fatoua villosa
Shi-Yun Su1, Jing-Jing Xue1, Guang-Yu Yang2
1Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.
Abstract:
Three new alkylated chalcones, villosins A - C (1 - 3), five known analogues, together with ten known coumarins, were isolated from Fatoua villosa. The structures of the new compounds were elucidated by extensive spectroscopic analysis, including 1D-, 2D-NMR, and MS data. Compounds 1 - 3 showed cytotoxicity against five kinds of human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7) with IC50 values ranging from 1.4 ± 0.1 to 5.7 ± 0.3 μm.
