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Functional network connectivity alterations in schizophrenia and depression.

Xing-Jie Wu1, Ling-Li Zeng2, Hui Shen2

  • 1Department of Control Engineering, Naval Aeronautical and Astronautical University, Yantai, Shandong 264001, China; College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China.

Psychiatry Research. Neuroimaging
|April 4, 2017
PubMed
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Major depressive disorder (MDD) and schizophrenia share symptoms due to overlapping brain network connectivity changes. Distinct alterations in these networks may help differentiate between MDD and schizophrenia.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Major depressive disorder (MDD) and schizophrenia exhibit significant symptom overlap.
  • The underlying neurobiological basis for these shared symptoms, particularly in functional network connectivity, remains poorly understood.

Purpose of the Study:

  • To investigate convergent and divergent alterations in functional network connectivity between MDD and schizophrenia patients compared to healthy controls.
  • To explore the role of the control network in the pathophysiology of both disorders.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) data were acquired from 20 MDD patients, 24 schizophrenia patients, and 43 healthy controls.
  • Group independent component analysis and functional network connectivity analysis were employed to examine brain network alterations.
Keywords:
Fronto-parietal control networkFunctional MRIFunctional network connectivityMajor depressive disorderSchizophrenia

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Main Results:

  • Both MDD and schizophrenia patients showed decreased positive connectivity in the fronto-parietal control network and decreased negative connectivity between the control and medial visual networks compared to controls.
  • MDD patients exhibited decreased negative connectivity between the control and auditory networks.
  • Schizophrenia patients displayed decreased positive connectivity between control and language networks, and decreased negative connectivity involving the dorsal attention network.

Conclusions:

  • Convergent functional connectivity alterations in the control network may underlie shared symptoms in MDD and schizophrenia.
  • Divergent connectivity patterns offer potential neurobiological markers for distinguishing between these two psychiatric disorders.
  • The control network plays a crucial role in the pathophysiology of both major depressive disorder and schizophrenia.