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WHITHER RHEOLOGY IN PHARMACY?

B Warburton1

  • 1Dept. of Pharmaceutics, The School of Pharmacy, University of London, London W.C. 1, England.

Journal of Texture Studies
|April 4, 2017
PubMed
Summary
This summary is machine-generated.

This review explores rheological techniques for pharmaceutical formulation, including injections, creams, and emulsions. It discusses interfacial film formation for emulsion stability and potential polymer-drug interaction detection using ultralow shear rates.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Physical Chemistry

Background:

  • Rheological techniques are crucial for understanding and optimizing pharmaceutical formulations.
  • The physical properties of formulations like injections, creams, and emulsions significantly impact their efficacy and stability.
  • Interfacial properties play a key role in the stability of complex emulsions.

Purpose of the Study:

  • To review the current applications of rheological techniques in pharmaceutical formulation.
  • To explore future developments and potential of these techniques.
  • To discuss theoretical approaches for assessing emulsion stability and polymer-drug interactions.

Main Methods:

  • Review of existing literature on rheological techniques in pharmaceutical formulation.

Related Experiment Videos

  • Theoretical analysis of interfacial film formation rates.
  • Discussion of ultralow shear rate methods for polymer-drug interaction detection.

    • Main Results:

    • Rheological techniques are widely applied in the formulation of injections, creams, and oil-in-water emulsions.
    • A theoretical framework for assessing interfacial film formation is presented, linking it to emulsion stability.
    • Ultralow shear rate methods show promise for detecting polymer-drug interactions.

    Conclusions:

    • Rheological methods are essential tools for pharmaceutical formulation development and quality control.
    • Further research into advanced rheological techniques can enhance emulsion stability and drug delivery systems.
    • Investigating polymer-drug interactions using rheology can lead to improved therapeutic efficacy.