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Related Experiment Videos

High sensitivity field asymmetric ion mobility spectrometer.

Mario A Chavarria1, Alessandro V Matheoud1, Philippe Marmillod1

  • 1Ecole Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.

The Review of Scientific Instruments
|April 5, 2017
PubMed
Summary

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A novel high sensitivity field asymmetric ion mobility spectrometer (FAIMS) was developed. This instrument achieves a 10 ppt limit of detection for acetone, demonstrating significant advancements in chemical detection sensitivity.

Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Instrument Development

Background:

  • Field Asymmetric Ion Mobility Spectrometry (FAIMS) is a powerful technique for chemical analysis.
  • Existing FAIMS systems can be limited by sensitivity and signal-to-noise ratio.
  • Advancements in electronics and detection methods are crucial for improving FAIMS performance.

Purpose of the Study:

  • To design, fabricate, and test a high-sensitivity FAIMS system.
  • To investigate the use of synchronous modulation/demodulation for enhanced signal-to-noise ratio.
  • To determine the limit of detection for standard chemical compounds using the developed FAIMS.

Main Methods:

  • A FAIMS system was constructed with a 10.6 eV UV photoionization source, a high voltage/high frequency ion filter, and a low noise ion detector.

Related Experiment Videos

  • The ion filter electronics generated square waveforms up to 1000 V at 1 MHz.
  • A synchronous modulation/demodulation technique was implemented, modulating the compensation voltage and demodulating the ion current.

    • Main Results:

    • The FAIMS system demonstrated high sensitivity in detecting standard chemical compounds.
    • The synchronous modulation/demodulation technique improved the signal-to-noise ratio.
    • An extrapolated limit of detection for acetone was determined to be 10 parts per trillion (ppt) with a 1-second averaging time.

    Conclusions:

    • The developed high-sensitivity FAIMS system offers enhanced performance for chemical analysis.
    • The synchronous modulation/demodulation technique is effective in improving FAIMS measurements, especially at low concentrations.
    • The system shows promise for sensitive detection of volatile organic compounds and other analytes.