Related Experiment Video
Updated: Feb 26, 2026
05:39
A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
Published on: June 13, 2025
966
Anti-Yo, chorea and hemiballismus: A case report
Lilach Goldstein1, Ruth Djaldetti1, Felix Benninger1
1Department of Neurology, Rabin Medical Center, Campus Beilinson, Petach Tiqwa, Israel.
Summary
A rare paraneoplastic syndrome occurred in a 68-year-old female with metastatic adenocarcinoma. Anti-Yo antibodies were detected, indicating an autoimmune response to cancer.
Area of Science:
- Neurology
- Oncology
- Immunology
Background:
- Paraneoplastic syndromes can manifest with neurological symptoms.
- Autoimmune responses can be triggered by underlying malignancies.
Observation:
- A 68-year-old female presented with involuntary movements.
- Standard neurological and cerebrospinal fluid evaluations were unremarkable.
- Whole body CT and biopsy confirmed metastatic adenocarcinoma.
Findings:
- The patient's autoimmune panel was positive for anti-Yo antibodies.
- This finding suggests a paraneoplastic neurological disorder.
Implications:
- Highlights the importance of considering paraneoplastic syndromes in patients with unexplained neurological symptoms and cancer.
- Underscores the diagnostic value of specific antibody testing in identifying autoimmune neurological disorders.
- Suggests potential therapeutic targets for managing paraneoplastic neurological disorders.
Related Concept Videos
01:28Disorders of the Skeletal Muscle
2.1K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.1K
01:15Parkinson's Disease: Overview
2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
01:13Seizures: Classification
1.8K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.8K