Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optimizing phase to enhance optical trap stiffness.

Michael A Taylor1,2

  • 1School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia. m.taylor@sbs.uq.edu.au.

Scientific Reports
|April 5, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sensitive label free imaging of 3D cell models with minimal toxicity using confocal reflectance.

Biomaterials science·2024
Same author

Brain-wide visual habituation networks in wild type and fmr1 zebrafish.

Nature communications·2022
Same author

Heterodyne Brillouin microscopy for biomechanical imaging.

Biomedical optics express·2021
Same author

Quantum-enhanced nonlinear microscopy.

Nature·2021
Same author

Sound generation in zebrafish with Bio-Opto-Acoustics.

Nature communications·2020
Same author

Diffuse light-sheet microscopy for stripe-free calcium imaging of neural populations.

Journal of biophotonics·2018
Same journal

Poly(bromophenol blue)/CoSn(OH)<sub>6</sub> cubic particles modified pencil graphite electrode for electrochemical determination of diphenhydramine.

Scientific reports·2026
Same journal

Dietary Chlorella, Spirulina, and acidifier modulate jejunal cytokine-related gene expression in broiler chickens.

Scientific reports·2026
Same journal

Perceived physical activity barriers in university students: associations with fatigue and eating behaviours.

Scientific reports·2026
Same journal

Refuge limitation structures habitat use in agricultural landscapes: evidence from Sunda pangolins.

Scientific reports·2026
Same journal

Lightweight stateless transaction verification with outsourced witness updates for UTXO blockchains.

Scientific reports·2026
Same journal

Efficacy of historical context and exogenous features on deep learning for cooling load forecasting in chilled water plants.

Scientific reports·2026
See all related articles

A new algorithm dramatically speeds up optical tweezers phase optimization, reducing convergence time from days to minutes. This breakthrough enhances trap stiffness and sensitivity for advanced optical trapping applications.

Area of Science:

  • Optical physics
  • Nanotechnology
  • Biophysics

Background:

  • Optical tweezers are crucial tools in manipulating microscopic objects.
  • Current phase optimization algorithms for optical tweezers are computationally intensive, requiring days for convergence.
  • This limitation hinders the practical application of enhanced optical trapping techniques.

Purpose of the Study:

  • To develop a significantly faster algorithm for phase optimization in optical tweezers.
  • To quantify the enhancement in trap stiffness and measurement sensitivity achievable with phase-only control.
  • To compare phase-only control with full wavefront shaping for optical trapping.

Main Methods:

  • Introduction of a novel, efficient algorithm for computing optimized phase profiles in optical tweezers.

Related Experiment Videos

  • Characterization of trap stiffness enhancement based on particle size, refractive index, and optical polarization.
  • Comparative analysis of phase-only control versus full wavefront shaping, including amplitude and polarization effects.
  • Main Results:

    • The new algorithm reduces phase optimization time from days to minutes.
    • Phase-only control achieved a 62-fold increase in trap stiffness for 10 μm silica spheres.
    • Full wavefront shaping, including amplitude and polarization, offered marginal additional enhancement (1.26x and 1.01x).

    Conclusions:

    • The developed algorithm offers a substantial acceleration of optical tweezers phase optimization.
    • Phase-only control provides nearly the full trapping enhancement potential of complex wavefront shaping.
    • This advancement will enable broader and more sophisticated applications of optical trapping and wavefront optimization.