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Related Experiment Videos

Non-invasive Brain Stimulation for Essential Tremor.

Ludy C Shih1, Alvaro Pascual-Leone2

  • 1Division of Movement Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

Tremor and Other Hyperkinetic Movements (New York, N.Y.)
|April 5, 2017
PubMed
Summary

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Non-invasive brain stimulation shows promise for essential tremor (ET) treatment. Studies suggest targeting the cerebellum and rigorous characterization are key for developing effective therapies.

Area of Science:

  • Neuroscience
  • Neurology
  • Biomedical Engineering

Background:

  • Growing interest in non-invasive brain stimulation (NIBS) for essential tremor (ET) diagnosis and treatment.
  • Diverse stimulation techniques, targets, and paradigms have been employed in prior research.
  • Need for comparative analysis of existing studies to refine methodologies.

Purpose of the Study:

  • To review and compare existing literature on NIBS for ET.
  • To evaluate the rationale and methods used in previous studies.
  • To identify critical factors for advancing NIBS therapies for ET.

Main Methods:

  • Systematic literature search of the PubMed database.
  • Keywords included various transcranial stimulation techniques (TMS, tDCS, tACS) and essential tremor.
Keywords:
Essential tremormotor physiologyneuromodulationnon-invasive brain stimulation

Related Experiment Videos

  • Analysis focused on stimulation parameters, target locations, and reported outcomes.

    • Main Results:

    • Single-pulse TMS of the motor cortex can reset tremor.
    • Evidence suggests potential alterations in motor cortical excitability and cerebello-brain inhibition in ET.
    • Repetitive TMS, theta burst stimulation, tDCS, and tACS show preliminary tremor reduction, especially with daily sessions.

    Conclusions:

    • Various stimulation paradigms and targets have been explored, with increasing focus on cerebellar stimulation.
    • Rigorous assessment of coil design, stimulation protocols, target selection rationale, and patient phenotyping is crucial.
    • These elements are critical for translating preliminary findings into effective ET stimulation therapies.