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Related Experiment Videos

Alphavirus-Based Vaccines.

Kenneth Lundstrom1

  • 1PanTherapeutics, Rue des Remparts 4, Lutry, 1095, Switzerland. lundstromkenneth@gmail.com.

Methods in Molecular Biology (Clifton, N.J.)
|April 5, 2017
PubMed
Summary
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Immunobiology and immunotherapy of COVID-19.

Progress in molecular biology and translational science·2025

Alphavirus vectors show promise for vaccines against viruses and tumors. While effective in animal models, human clinical trials remain limited.

Area of Science:

  • Virology
  • Vaccinology
  • Immunology

Background:

  • Alphavirus vectors, derived from viruses like Semliki Forest virus, Sindbis virus, and Venezuelan equine encephalitis virus, are utilized in vaccine development.
  • These vectors have been explored for their potential in combating viral infections and cancer.

Purpose of the Study:

  • To review the application of alphavirus-based vectors for vaccine development.
  • To summarize immunization strategies and outcomes in preclinical models.
  • To highlight the progress and limitations of alphavirus-based vaccines, including those against Chikungunya virus.

Main Methods:

  • Engineering of alphavirus-based vectors from Semliki Forest virus, Sindbis virus, and Venezuelan equine encephalitis virus.
  • Immunization of preclinical animal models using naked RNA replicons, recombinant viral particles, and DNA-RNA vectors.
Keywords:
AlphavirusesCancer vaccinesImmunizationNeutralizing antibodiesProtectionViral vaccines

Related Experiment Videos

  • Targeting viral surface proteins and tumor antigens for immune response induction.

    • Main Results:

    • Alphavirus-based vectors successfully elicited strong immune responses in animal models.
    • Protection against lethal viral challenges and tumor cell inoculation was demonstrated.
    • Vaccines against Chikungunya virus have been developed due to alphavirus epidemic potential.

    Conclusions:

    • Alphavirus-based vectors are a promising platform for vaccine development against various targets.
    • Preclinical success has been observed, but further clinical translation in humans is needed.