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Related Experiment Videos

MicroBubble activated acoustic cell sorting.

M A Faridi1, H Ramachandraiah1, I Iranmanesh1,2

  • 1Division of Proteomics and Nanobiotechnology, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.

Biomedical Microdevices
|April 5, 2017
PubMed
Summary

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This summary is machine-generated.

A novel microfluidic method uses microbubbles to acoustically sort cells, overcoming limitations of traditional acoustophoresis. This microBubble-Activated Acoustic Cell Sorting (BAACS) technique offers efficient cell separation for point-of-care applications.

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Acoustic Cell Manipulation

Background:

  • Acoustophoresis enables acoustic manipulation of cells in microfluidic channels, crucial for cell sorting.
  • Current acoustophoresis methods rely on inherent cell properties, limiting clinical laboratory applications.
  • Targeted cell separation requires advanced techniques beyond inherent physical property reliance.

Purpose of the Study:

  • To introduce a microfluidic-based microBubble-Activated Acoustic Cell Sorting (BAACS) method.
  • To enable cell separation based on specific binding to antibody-conjugated microbubbles.
  • To expand acoustic cell manipulation possibilities for point-of-care applications.

Main Methods:

  • Utilized microfluidic channels for cell manipulation using ultrasonic standing waves.
Keywords:
AcoustophoresisCell sortingContrast agentMicrobubbleMicrofluidic separation

Related Experiment Videos

  • Employed antibody-conjugated microbubbles for specific target cell capture.
  • Leveraged acoustic contrast differences between cells and microbubbles for separation.

    • Main Results:

    • Demonstrated separation of a cancer cell line with over 75% efficiency.
    • Achieved 100% migration of microbubble-cell conjugates to pressure antinodes.
    • Showcased the potential for improved sorting efficiency with enhanced affinity-capture.

    Conclusions:

    • The BAACS technique offers a novel approach to acoustic cell sorting.
    • BAACS overcomes limitations of traditional acoustophoresis by utilizing microbubbles for specific cell targeting.
    • This method provides promising cell-sorting solutions for point-of-care diagnostics and research.