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Updated: Aug 8, 2026

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
Syntheses and structure-membrane active antimicrobial activity relationship of alkylamino-modified glucose,
Hatsuo Yamamura1,2, Takahiro Mabuchi2, Tomoki Ishida1
1Life and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Nagoya, Japan.
Abstract:
Antimicrobial alkylamine-modified sugars were prepared. Microwave-assisted click reaction efficiently achieved poly-functionalization of oligo- and polysaccharides. The sugars exhibited a unique relationship of their bacterial membrane permeabilization and antimicrobial activity with the number of functional groups and the structure of the molecular scaffold. It shows that the assembly of the functional groups is necessary for being antimicrobial. The amylose derivatives also exhibited synergy to minimize the necessary dose of conventional antibiotics and increase their antimicrobial potency.
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