Related Experiment Video
Updated: Jul 17, 2026

10:43
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
Esophageal cancer's 100 most influential manuscripts: a bibliometric analysis
A G M T Powell1,2, D L Hughes2, J Brown2
1Division of Cancer and Genetics, Cardiff University, University Hospital of Wales, Cardiff, UK.
Summary
This bibliometric analysis identifies the 100 most cited esophageal cancer (EC) papers. Key research themes include EC pathology, management, and prognosis, guiding future studies in this field.
Area of Science:
- Oncology
- Gastroenterology
- Bibliometrics
Background:
- Esophageal cancer (EC) research has significantly advanced, yet a clear overview of its most influential publications is lacking.
- Understanding the foundational studies in EC is crucial for identifying key research trends and guiding future investigations.
Purpose of the Study:
- To identify and analyze the 100 most cited manuscripts in esophageal cancer research.
- To map the evolution of research themes, influential journals, authors, and institutions in the field of EC.
Main Methods:
- A bibliometric analysis was conducted using the Web of Science database.
- Search terms included 'esophageal cancer,' 'esophageal carcinoma,' 'oesophageal cancer,' 'oesophageal carcinoma,' and 'gastroscopy.'
- The top 100 most cited English-language full manuscripts were analyzed by topic, journal, author, year, and institution.
Main Results:
- The analysis identified 121,556 eligible papers, with a median citation count of 406.5.
- The most cited paper focused on perioperative chemotherapy for EC (1833 citations).
- Gastroenterology published the most papers, while The New England Journal of Medicine received the most citations. The USA was the leading country for publications.
Conclusions:
- The most influential esophageal cancer (EC) research centers on pathology, management, and prognosis.
- This bibliometric review highlights pivotal studies, offering a roadmap for understanding popular research themes and directing future scientific inquiry in EC.
Related Concept Videos
Cancer
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Barrett Esophagus-I: Introduction
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...

