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Which dietary components modulate longitudinal growth?

Galia Gat-Yablonski1, Michal Yackobovitch-Gavan, Moshe Phillip

  • 1aNational Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Petach Tikva bSackler Faculty of Medicine, Tel Aviv University, Tel Aviv cFelsenstein Medical Research Center, Petach Tikva, Israel.

Current Opinion in Clinical Nutrition and Metabolic Care
|April 5, 2017
PubMed
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Proper linear growth in children requires a balance of macronutrients and micronutrients. While specific optimal compositions are unknown, combined nutrient support is a promising clinical approach for skeletal development.

Area of Science:

  • Pediatric Nutrition
  • Skeletal Development
  • Nutritional Biochemistry

Background:

  • Linear growth in children is significantly influenced by nutritional status.
  • Skeletal growth necessitates diverse nutritional factors for energy and structural components, including proteins, lipids, carbohydrates, and micronutrients.
  • The precise nutritional requirements and optimal compositions for healthy growth remain incompletely understood.

Purpose of the Study:

  • To review current understanding of essential nutritional factors for linear growth.
  • To explore the roles of macronutrients and micronutrients in skeletal development.
  • To identify knowledge gaps regarding optimal nutritional strategies for child growth.

Main Methods:

  • Literature review of recent findings on nutrient roles in linear growth.

Related Experiment Videos

  • Analysis of studies examining macronutrient and micronutrient effects.
  • Synthesis of evidence on regulatory functions and gut microbiome interactions.
  • Main Results:

    • Macronutrients and micronutrients serve as essential building blocks and enzyme cofactors.
    • These nutrients also act as regulatory factors, influencing linear growth and gut microbiome composition.
    • Studies highlight the impact of proteins and amino acids on growth processes.

    Conclusions:

    • Most research focuses on single micronutrient deficiencies, which is less reflective of real-world scenarios.
    • Combined macro- and micronutrient supplementation is a clinically rational approach to support growth in various settings.
    • Further research is needed to determine optimal dosages and compositions for comprehensive nutritional support.