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New developments in uveitis associated with HLA B27.

James T Rosenbaum1

  • 1aCasey Eye Institute, Oregon Health and Science University bLegacy Devers Eye Institute, Portland, Oregon, USA.

Current Opinion in Rheumatology
|April 5, 2017
PubMed
Summary
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Recent research highlights human leukocyte antigen (HLA) B27-associated uveitis, a common manifestation of axial spondyloarthritis. Studies since 2015 offer new insights into its prevalence, genetics, and treatment.

Area of Science:

  • Ophthalmology
  • Rheumatology
  • Immunogenetics

Background:

  • Uveitis is a frequent extra-articular manifestation of axial spondyloarthritis.
  • Acute anterior uveitis (AAU) is strongly associated with human leukocyte antigen (HLA) B27.

Purpose of the Study:

  • To review recent publications on HLA B27-associated uveitis and axial spondyloarthritis.
  • To summarize advancements in understanding the prevalence, genetics, and treatment of this condition.

Main Methods:

  • Literature review of studies published since 2015.
  • Analysis of research on HLA B27-associated uveitis, axial spondyloarthritis, and acute anterior uveitis (AAU).

Main Results:

  • Recent studies have clarified the worldwide prevalence of HLA B27-associated uveitis and axial spondyloarthritis in AAU patients.

Related Experiment Videos

  • New genetic insights and clinical implications of AAU have emerged.
  • Treatment strategies for uveitis, particularly in spondyloarthropathy, have progressed.

    • Conclusions:

    • Despite being recognized for decades, recent findings offer novel perspectives on HLA B27-associated uveitis and its link to spondyloarthritis.
    • Understanding the microbiome and Ebola-related uveitis may provide further clues to AAU pathogenesis.