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Related Experiment Videos

Turing mechanism underlying a branching model for lung morphogenesis.

Hui Xu1,2, Mingzhu Sun1,2, Xin Zhao1,2

  • 1Institute of Robotics and Automatic Information System, Nankai University, Tianjin, China.

Plos One
|April 5, 2017
PubMed
Summary
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Mathematical modeling reveals Turing instability drives lung branching morphogenesis. Gene regulation of Turing wavelength controls the switch between tip bifurcation and side branching patterns during lung development.

Area of Science:

  • Developmental Biology
  • Mathematical Biology
  • Systems Biology

Background:

  • Mammalian lung development involves branching morphogenesis, with tip bifurcation and side branching as key processes.
  • The underlying mechanisms of lung branching morphogenesis are not fully understood.
  • Previous work established a biological model for lung branching pattern formation.

Purpose of the Study:

  • To elucidate the mathematical mechanisms governing lung branching patterns.
  • To investigate the role of Turing instability in lung branching.
  • To connect mathematical models to genetic control of branching modes.

Main Methods:

  • Decoupling a branching model to demonstrate Turing instability.
  • Performing Turing instability analysis on branching patterns.

Related Experiment Videos

  • Utilizing dispersion relation analysis to study Turing wavelength effects.

    • Main Results:

    • Turing instability underlies lung branching patterns, manifesting as spot patterns with high local morphogen concentration.
    • Sparse spot patterns correlate with tip bifurcation, while dense spot patterns correlate with side branching.
    • Decreasing Turing wavelength shifts patterns from sparse to dense, favoring side branching over tip bifurcation.

    Conclusions:

    • Turing patterns provide a mathematical basis for lung branching morphogenesis.
    • Gene regulation of Turing wavelength likely controls the switch between tip bifurcation and side branching.
    • This study offers new insights into branching pattern formation in lungs and other biological systems.