Related Experiment Video
Updated: Aug 11, 2026
Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Published on: July 23, 2016
Anterior segment migration of dexamethasone implant: risk factors, complications, and management
Ehsan Rahimy1, Rahul N Khurana
1aDepartment of Ophthalmology, Palo Alto Medical Foundation, Palo AltobNorthern California Retina Vitreous Associates, Mountain ViewcDepartment of Ophthalmology, University of California, San Francisco, California, USA.
Purpose Of Review:
To describe the risk factors, clinical course, and complications related to anterior segment migration of a dexamethasone (DEX) intravitreal implant, and review over potential management strategies.
Recent Findings:
Recent reports have demonstrated that migration of a DEX implant into the anterior chamber may occur in patients with higher risk ocular characteristics. Although a relatively rare occurrence, DEX implant migration carries the possibility of inducing potentially vision-threatening corneal endothelial decompensation and edema.
Summary:
Any combination of previous pars plana vitrectomy, an open/defective lens capsule, and/or iris defects may increase the risk of DEX implant migration into the anterior chamber. In the setting of a DEX implant that has moved into the anterior segment with corneal edema already present, urgent removal of the implant is warranted to reduce the risk of permanent visual compromise.
