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N-methyl-D-aspartate (NMDA) receptors control respiratory off-switch in cat
A S Foutz1, J Champagnat, M Denavit-Saubié
1Laboratoire de Physiologie Nerveuse, C.N.R.S., Gif-sur-Yvette, France.
Neuroscience Letters
|May 3, 1988
Abstract:
Functionally active N-methyl-D-aspartate (NMDA) receptors on cat medullary respiratory neurones were revealed by local iontophoretic application of DL-2-amino-7-phosphonoheptanoic acid (AP7). Blockade of NMDA receptors by systemic administration of NMDA antagonists (MK-801, phencyclidine, ketamine, AP7) in vagotomized cats increased the duration of inspiration (Ti) without increasing expiration and caused an apneustic breathing pattern. The increase in Ti which followed systemic MK-801, was accompanied by a shift and complete reversal of early expiratory neuronal discharge in relation to phrenic nerve discharge.