Related Experiment Videos
Novel boronic acid derivatives of bis(indolyl) methane as anti-MRSA agents
Santi M Mandal1, Rupa Pegu2, William F Porto3
1Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, India.
Bioorganic & Medicinal Chemistry Letters
|April 6, 2017
Abstract:
Towards the search for a new generation of antibiotics to control methicillin-resistant Staphylococcus aureus (MRSA), the design and synthesis of various bis indolyl methane (BIM) derivatives based on their different electron donor and acceptor properties of the substituents have been made, in which boronic acid derivatives of BIM are found to be active against MRSA. The observed evidence with the lead compound reveals their strong anti-MRSA activity, which paves the way of design and further development of a new generation antibiotics.