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Related Experiment Videos

Force-driven growth of intercellular junctions.

Mohammad Tehrani1, Alireza S Sarvestani1

  • 1Department of Mechanical Engineering, Ohio University, Athens, OH 45701, United States.

Journal of Theoretical Biology
|April 6, 2017
PubMed
Summary

Mechanical force influences cell junction growth. A new model shows catch bonds, unlike slip bonds, exhibit cell mechanotransduction hallmarks under pulling forces.

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Area of Science:

  • Biophysics
  • Cell Biology
  • Materials Science

Background:

  • Mechanical force is critical for cell-cell junction formation and growth.
  • Cadherins mediate intercellular adhesion, and force transmission through them correlates with junction enlargement.

Purpose of the Study:

  • To propose a physical model for cell-cell junction structural evolution under pulling forces.
  • To compare the force-dependent behavior of slip and catch bonds in cadherin clusters.

Main Methods:

  • Utilized the Bell-Dembo-Bongard thermodynamic model.
  • Developed a physical model for junction structural evolution under pulling tractions.
  • Conducted comparative analysis of slip and catch bond clusters under varying Ca2+ concentrations.

Main Results:

  • Clusters of catch bonds, unlike slip bonds, display characteristics of cell mechanotransduction when subjected to pulling forces.
  • The observed mechanotransduction is a passive thermodynamic response.
  • Mechanical work from pulling forces dictates the free energy landscape of the junction.

Conclusions:

  • Catch bonds play a significant role in cell mechanotransduction, regulated by mechanical forces.
  • The thermodynamic model provides insights into the force-dependent structural dynamics of cell-cell junctions.
  • Cadherin's adhesive state (slip vs. catch) is crucial for its response to mechanical stimuli.
Keywords:
Gibbs free energyGrowthMechanotransduction

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