[Research progress of skin-derived precursor cells].

Area of Science:

• Regenerative Medicine
• Developmental Biology
• Cell Biology

Background:

• Skin-derived precursor cells (SKPs) are a novel cell population originating from the embryonic neural crest.
• These cells can be isolated from both embryonic and adult dermis, offering accessible and abundant sources.
• SKPs possess multipotent differentiation potential and lack ethical concerns, making them valuable for research and clinical applications.

Purpose of the Study:

• To review the developmental and anatomical origins of SKPs.
• To explore the potential applications of SKPs in regenerative medicine.
• To highlight the significance of SKPs in tissue repair and therapeutic strategies.

Main Methods:

• Literature review of studies on SKPs' origins and applications.
• Analysis of SKPs' developmental pathways and anatomical distribution.
• Evaluation of SKPs' differentiation potential and clinical relevance in regenerative medicine.

Main Results:

• SKPs originate from the embryonic neural crest, with varying sources across the body.
• SKPs are predominantly found in the dermis, particularly in the dermal papilla (DP), identified as a niche.
• The multipotency of SKPs supports their use in autologous transplantation for tissue repair.

Conclusions:

• SKPs represent a promising cell source for regenerative medicine due to their origin, accessibility, and multipotency.
• Understanding the developmental origins and anatomical niches of SKPs is crucial for optimizing their therapeutic use.
• SKPs hold significant potential for wound healing, organ regeneration, and disease treatment, emphasizing their importance in tissue repair.