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Overexpression of GSN could decrease inflammation and apoptosis in EAE and may enhance vitamin D therapy on EAE/MS.

Jifang Gao¹, Zhaoyu Qin², Xinyuan Guan¹

¹Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, 44#Wenhua Xi Road, Jinan, 250012, Shandong, P.R. China.

Scientific Reports

|April 6, 2017

Summary

Gelsolin (GSN) shows therapeutic potential for multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE). Increasing GSN levels can delay EAE onset and severity, potentially enhancing vitamin D therapy for MS.

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Area of Science:

Neuroimmunology
Molecular Biology

Background:

Gelsolin (GSN) levels are decreased in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE).
The therapeutic role of GSN in EAE/MS remains largely uninvestigated.

Purpose of the Study:

To investigate the protective effects of gelsolin (GSN) in experimental allergic encephalomyelitis (EAE).
To explore the potential of combining GSN and vitamin D for enhanced EAE/MS therapy.

Main Methods:

Administered GSN-overexpressing lentivirus (LV-GSN) via lateral ventricle and caudal vein in EAE models.
Investigated the interaction between vitamin D and GSN, including the role of the vitamin D receptor (VDR).
Utilized GSN RNA interference and VDR gene manipulation in PC12 cells to confirm GSN's anti-apoptotic function.

Main Results:

GSN administration delayed EAE onset and reduced disease severity.
Combined vitamin D and GSN treatment improved EAE symptoms and slowed disease progression.
Vitamin D's effect on GSN is mediated via the vitamin D receptor (VDR).
GSN demonstrated anti-apoptotic properties in PC12 cells.

Conclusions:

GSN exhibits therapeutic potential for EAE/MS.
Increasing GSN levels may enhance the efficacy of vitamin D therapy in EAE/MS.
GSN's anti-apoptotic function contributes to its protective effects in EAE.