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The Correlation of CD206, CD209, and Disease Severity in Behçet's Disease with Arthritis

Bunsoon Choi1, Chang-Hee Suh2, Hyoun-Ah Kim2

  • 1Department of Microbiology, Ajou University School of Medicine, Suwon, Republic of Korea.

Mediators of Inflammation
|April 6, 2017
PubMed

Insights

Pattern recognition receptors are implicated in Behçet

Area of Science:

  • Immunology
  • Rheumatology
  • Cell Biology

Background:

  • Behçet's disease (BD) is a complex inflammatory disorder.
  • The role of pattern recognition receptors (PRRs) in BD pathogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the expression of specific PRRs in patients with Behçet's disease.
  • To correlate PRR expression with disease activity and clinical manifestations.

Main Methods:

  • Flow cytometry was used to analyze PRR frequencies (CD11b, CD11c, CD32, CD206, CD209, dectin-1) in BD patients.
  • Plasma cytokine levels (IL-18, IL-23, IL-17A) were measured.
  • Patients included active BD (n=13), inactive BD (n=13), rheumatoid arthritis controls (n=19), and healthy controls (n=19).

Main Results:

  • Frequencies of CD11b+ and CD32+ cells were elevated in active BD patients compared to healthy controls.
  • Disease severity correlated with CD11c+, CD206+, and CD209+ expression in leukocytes, and CD11b+, CD11c+, CD206+, CD209+, and Dectin-1+ in granulocytes.
  • Plasma IL-17A differed between healthy controls and active BD patients, while IL-18 levels varied between active and inactive BD.

Conclusions:

  • Specific PRR expressions are altered in Behçet's disease.
  • PRR expression patterns correlate with disease activity and joint symptoms in BD.

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