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Published on: December 16, 2021
Chronic Granulomatous Disease Mimicking Colonic Crohn's Disease Successfully Treated with Infliximab
Armando Peixoto1, Rosa Coelho1, Tiago Maia2
1Department of Gastroenterology, Centro Hospitalar São João, Porto, Portugal; WGO Porto Training Center, Porto, Portugal.
Abstract:
Chronic granulomatous disease (CGD) is a genetically induced disease caused by mutations in one of the components of the NADPH-oxidase in phagocytes, characterized by life-threatening bacterial and fungal infections and granuloma formation. Treatment includes prevention of infectious complications and immunomodulation. However, a standard strategy is not yet defined. The authors report an X-linked CGD female carrier who presented during adulthood with diarrhea and colorectal ulcers, with high impairment of quality of life. Induction with infliximab 5 mg/kg (weeks 0, 2, and 6) with infectious prophylaxis was initiated. She continued infliximab 5 mg/kg every 8 weeks with complete symptomatic response at 15 months.
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