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Iliac crest histomorphometry and skeletal heterogeneity in men
Xiaoyu Tong1, Inari S Burton1, Jukka S Jurvelin2
1Kuopio Musculoskeletal Research Unit (KMRU), Institute of Clinical Medicine, University of Eastern Finland, POB 1627, FIN-70211 Kuopio, Finland; Department of Applied Physics, University of Eastern Finland, POB 1627, FIN-70211 Kuopio, Finland.
Bone Reports
|April 6, 2017
Summary
Iliac crest bone structure differs between its inner and outer layers and from hip fracture sites. Iliac crest biopsies may not accurately represent other skeletal areas.
Area of Science:
- Orthopedic surgery
- Bone histomorphometry
- Skeletal biology
Background:
- Quantitative histomorphometry of male iliac crest cortical bone is understudied.
- Variations in cortical microarchitecture between the iliac crest and proximal femur fracture sites are unknown.
Purpose of the Study:
- To investigate the microarchitecture of external and internal iliac crest cortices.
- To compare iliac crest cortical bone with femoral neck and subtrochanteric femoral shaft.
Main Methods:
- Histomorphometric analysis of undecalcified iliac crest sections from 20 male cadavers (aged 18-82).
- Modified Masson-Goldner staining and analysis at low and high magnifications.
- Measurement of complete osteons and pore parameters within cortical bone.
Main Results:
- External iliac crest cortex showed greater width and osteon perimeter than internal cortex.
- Younger subjects had higher pore number, older subjects had higher pore perimeter.
- Iliac crest bone parameters differed significantly from femoral neck and subtrochanteric shaft, with some correlations noted between iliac crest and femoral neck.
Conclusions:
- Significant heterogeneity exists in cortical microarchitecture within the iliac crest and between the iliac crest and proximal femur sites.
- Standard iliac crest biopsies may not accurately reflect the cortical microarchitecture of other skeletal locations.