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Infection prevention for patients with acute leukemia using laminar air flow rooms
1Center for Adult Diseases, Osaka, Japan.
Abstract:
Infection prevention using laminar air flow (LAF) rooms was studied. For the effective and economical usage of LAF rooms, our trials with ozone decontamination were deemed very convenient and effective. In maintaining LAF clean, insects were found to be a critical factor regarding fungus contamination of LAF. As to its efficacy of infection prevention, LAF decreased infection during remission induction from 113/100 to 28/100. The infections reduced by LAF were pneumonia, upper respiratory infection and skin abscess, while sepsis and perianal infection were not affected. Treatment in LAF rooms also seemed to have comparable influence on interstitial pneumonitis after bone marrow transplantation.
Insights
Laminar air flow (LAF) rooms significantly reduce infections like pneumonia and skin abscesses during remission induction. Ozone decontamination and insect control are key to maintaining LAF room cleanliness and effectiveness.
Area of Science:
- Infection Prevention and Control
- Environmental Hygiene in Healthcare Settings
- Microbiology and Mycology
Background:
- Laminar air flow (LAF) rooms are utilized for infection prevention in clinical settings.
- Maintaining the cleanliness of LAF rooms is crucial for their efficacy.
- Fungal contamination, often linked to insect presence, poses a challenge to LAF room hygiene.
Purpose of the Study:
- To evaluate the effectiveness of laminar air flow (LAF) rooms in infection prevention.
- To assess the utility of ozone decontamination for maintaining LAF room cleanliness.
- To identify critical factors influencing fungal contamination in LAF environments.
Main Methods:
- Trials involving ozone decontamination for LAF room cleaning.
- Monitoring insect populations as a factor in fungal contamination.
- Comparing infection rates before and after LAF room implementation during remission induction.
Main Results:
- Ozone decontamination proved convenient and effective for LAF room maintenance.
- Insects were identified as a critical factor in fungal contamination within LAF rooms.
- LAF rooms reduced infection rates from 113/100 to 28/100 during remission induction.
- Specific infections reduced include pneumonia, upper respiratory infections, and skin abscesses.
- Sepsis and perianal infections were not significantly affected by LAF.
- LAF treatment showed comparable effects on interstitial pneumonitis post-bone marrow transplantation.
Conclusions:
- Laminar air flow (LAF) rooms are effective in reducing certain infections, particularly during remission induction.
- Ozone decontamination offers an effective and economical method for maintaining LAF room hygiene.
- Controlling insect populations is essential for preventing fungal contamination in LAF environments.
- LAF rooms demonstrate significant benefits for infection control, with specific reductions in respiratory and skin infections.