[Is a once-daily dose of furosemide effective? Literature study into rational for dosing of short-acting diuretic]

- Furosemide is a widely used short-acting diuretic with a steep dose-response curve.- Furosemide is commonly prescribed once daily, but because of its short-acting nature it is questionable if a once-daily regiment is effective.- Different physiological and pathophysiological principles influence the effect and period of efficacy of furosemide.- Studies in both healthy subjects and different patient categories do demonstrate efficacy of furosemide once daily, but also that furosemide prescribed twice daily is more effective.- It is advised to combine furosemide treatment with a sodium-restricted diet, because this enhances the effects of the diuretic treatment.