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Updated: Jul 31, 2026
11:40
Quantitative Autonomic Testing
Published on: July 19, 2011
[Hypertensive urgency or high blood pressure variability?]
1I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
Terapevticheskii Arkhiv
|April 6, 2017
Summary
Hypertensive urgency (HU) in elderly patients often involves high blood pressure variability. Calcium antagonists, like amlodipine, effectively reduce this variability, lowering cardiovascular event risk.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Hypertensive urgency (HU) is a frequent concern, especially in elderly patients, often linked to severe asymptomatic hypertension and situational high blood pressure with significant variability.
- Short-acting antihypertensive drugs, while sometimes used, may paradoxically elevate cardiovascular event risk in these scenarios.
Discussion:
- Increased blood pressure variability (BPV) is a recognized independent predictor of cardiovascular events (CVE).
- Calcium antagonists, particularly amlodipine, demonstrate a significant capacity to mitigate BPV compared to other antihypertensive classes.
Key Insights:
- Calcium antagonists are effective in managing hypertensive urgency by reducing blood pressure variability.
- Amlodipine shows promise in lowering the risk of cardiovascular events associated with high BPV.
Outlook:
- Calcium antagonists should be considered first-line therapy for patients exhibiting high blood pressure variability.
- Further research into amlodipine's role in preventing CVE in hypertensive urgency is warranted.
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