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Elevated serum IL-39 in patients with ST-segment elevation myocardial infarction was related with left ventricular
Yu Luo1, Feng Liu2, Huadong Liu2
1Department of Gerontology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, No.1017 Dongmen North Road, Shenzhen, 518020, PR China.
Aim:
To investigate the changes and significance of circulating IL-39 in patients with acute coronary syndrome (ACS).
Patients & Methods:
Serum IL-39 levels in ACS patients and normal coronary arteries were measured. The correlations of IL-39 with high-sensitivity CRP, cTnI, N-terminal of the prohormone brain natriuretic peptide (NTproBNP) and left ventricular ejection fraction were investigated.
Results:
The serum levels of IL-39 in ACS patients were significantly increased. IL-39 levels were positively correlated with NTproBNP, high-sensitivity CRP and cTnI, negatively correlated with left ventricular ejection fraction in ACS patients. The most significant correlation arose between serum IL-39 and NTproBNP in STEMI patients (r = 0.8309; p < 0.0001).
Conclusion:
Circulating level of IL-39 might be a predictor of cardiac systolic dysfunction in ST-segment elevation myocardial infarction patients.