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Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

siRNA Delivery Strategies: A Comprehensive Review of Recent Developments

Katyayani Tatiparti1, Samaresh Sau2, Sushil Kumar Kashaw3,4

  • 1Use-Inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA. katyayani.tatiparti@wayne.edu.

Nanomaterials (Basel, Switzerland)
|April 6, 2017
PubMed

Insights

Small interfering RNA (siRNA) offers therapeutic potential for gene regulation in diseases like cancer. Developing effective nanoparticulate delivery systems is crucial to overcome challenges like instability and poor cell membrane crossing.

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Gene Therapy

Background:

  • Small interfering RNA (siRNA) acts as a post-transcriptional gene regulator for various diseases, including cancer, viral infections, and autoimmune disorders.
  • siRNA's potential in cancer therapy includes suppressing oncogenes and targeting tumor suppressor genes.
  • Its specificity and adaptability make it suitable for personalized gene therapy.

Purpose of the Study:

  • To provide a comprehensive review of current siRNA delivery challenges.
  • To highlight strategies for developing effective nanoparticulate delivery systems for siRNA.

Main Methods:

  • Review of existing literature on siRNA delivery systems.
  • Analysis of challenges associated with naked siRNA (instability, immunogenicity, poor cell penetration).
  • Exploration of nanoparticulate strategies to enhance siRNA delivery.

Main Results:

  • Naked siRNA exhibits instability in bloodstream, poor cell membrane permeability, and immunogenicity.
  • Nanoparticulate delivery systems are essential for overcoming these limitations.
  • Various strategies are being explored to optimize siRNA encapsulation and targeted delivery.

Conclusions:

  • Effective siRNA delivery systems are critical for realizing its therapeutic potential.
  • Nanoparticulate formulations represent a promising approach to address siRNA delivery challenges.
  • Further research into optimized delivery systems will advance siRNA-based therapies.
Keywords:
RNAicancer therapydelivery systemsgene deliverynanoparticlessiRNAtargeted deliverytumor

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