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Migration of neutrophils in experimental asthma
1Department of Internal Medicine and Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Japan.
Annals of Allergy
|June 1, 1988
Abstract:
Ovalbumin (OA) aerosol exposure caused an increase in phospholipase (PLase) activity in guinea pig lung membranes and in leukotriene B4 (LTB4) in lung lavages with subsequent neutrophil influx into lung lavages. These results suggest that activation of PLase after exposure to OA aerosol triggers an increase in LTB4 synthesis resulting in neutrophil influx into the airways.