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Related Experiment Videos

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.

Jill M Pulley1, Jana K Shirey-Rice1, Robert R Lavieri1

  • 11 Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center , Nashville, Tennessee.

Assay and Drug Development Technologies
|April 6, 2017
PubMed

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Summary

Vanderbilt links genetic data with electronic health records to accelerate drug discovery and repurposing. An expert incubator leverages this resource to find new drug indications using human genetics.

Area of Science:

  • Genomics
  • Pharmacology
  • Bioinformatics

Background:

  • The integration of human genetic data with longitudinal electronic medical records presents significant opportunities for drug development.
  • Practical application requires innovative organizational structures to manage and utilize these complex datasets.

Purpose of the Study:

  • To outline organizational innovations for leveraging linked genetic and electronic health record data in drug development.
  • To introduce the Accelerating Drug Development and Repurposing Incubator as a resource for drug discovery and repurposing.

Main Methods:

  • Creation of a de-identified database linking over 2.6 million electronic health records with the BioVU DNA biobank (>230,000 samples).
  • Establishment of a multidisciplinary incubator comprising experts in therapeutic areas, basic and clinical science, legal, business, and operational domains.
Keywords:
BioVUPheWASgeneticsrepurposingtranslational research

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  • Utilizing the natural experiment of human genetics to support drug indication finding projects.

    • Main Results:

    • Vanderbilt has developed a substantial, queryable resource of linked genetic and de-identified electronic health records.
    • The Accelerating Drug Development and Repurposing Incubator is operational, supporting a pipeline of drug indication finding projects.

    Conclusions:

    • Linking human genetic data with electronic medical records offers extraordinary potential for drug development.
    • Organizational innovations, exemplified by Vanderbilt's BioVU and the Incubator, are crucial for realizing this potential in accelerating drug discovery and repurposing.