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Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
Impact of multidisciplinary teams for management of intestinal failure in children
Christina Belza1, Paul W Wales
1aGroup for Improvement of Intestinal Function and Treatment (GIFT) bDivision of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Insights
Pediatric intestinal rehabilitation programs (IRPs) improve survival and enteral autonomy in children with intestinal failure. These programs also reduce complications, though methodological limitations exist in current literature.
Area of Science:
- Pediatric Gastroenterology
- Intestinal Failure Management
- Clinical Nutrition
Background:
- Intestinal failure (IF) in children presents significant management challenges.
- Intestinal rehabilitation programs (IRPs) have emerged as a critical intervention.
- Recent literature continues to evaluate the efficacy of IRPs in pediatric populations.
Purpose of the Study:
- To systematically review recent literature on the impact of pediatric intestinal rehabilitation programs (IRPs).
- To assess the effect of IRPs on the management of intestinal failure in children.
Main Methods:
- Literature search for publications post-2013 systematic review on pediatric IRPs.
- Analysis of four additional publications detailing IRP impact.
- Evaluation of outcomes including survival, enteral autonomy, and complication rates.
Main Results:
- Continued evidence supports improved survival rates with pediatric IRPs.
- Ent腸al autonomy is enhanced in children undergoing IRP.
- IRPs are associated with a reduction in complications, including liver dysfunction, central venous catheter issues, and need for transplantation.
Conclusions:
- Pediatric IRPs provide substantial benefits for children with intestinal failure.
- Methodological limitations in current studies hinder definitive interpretation.
- Enhanced collaboration in IRP research is crucial for future advancements in the field.
Purpose Of Review:
To review the recent literature related to the impact of an intestinal rehabilitation program (IRP) on the management of intestinal failure in children.
Recent Findings:
As publication of a systematic review of pediatric IRPs in 2013, there have been four publications further describing the impact of IRPs in children with intestinal failure. The results continue to support an improvement in survival and enteral autonomy, and a decrease in complications related to liver dysfunction, central venous catheters, and transplantation.
Summary:
Pediatric IRPs offer significant advantage to outcomes of children with intestinal failure. The literature is difficult to interpret because of methodological limitations. IRP collaboration is necessary to further advance the field.
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