[Extramammary Paget's disease with internal malignancies].

Area of Science:

• Oncology
• Dermatology

Background:

• Extramammary Paget's disease (EP) is associated with underlying adnexal and internal malignancies.
• Previous reviews suggest a link between EP location and internal malignancy type.

Purpose of the Study:

• To compare the incidence and characteristics of internal malignancies associated with EP in Japanese patients versus Caucasian data.
• To evaluate if the location-specific association of internal malignancies holds true for Japanese EP cases.

Main Methods:

• Retrospective analysis of 68 Extramammary Paget's disease cases from a single clinic over 30 years.
• Comparison of findings with a comprehensive literature review (Chanda, 1985) of 197 EP cases.
• Analysis of 39 reported Japanese EP cases with associated internal malignancies.

Main Results:

• 14.7% of Japanese EP patients in this study had associated internal malignancy, compared to 28.8% in Chanda's review.
• In Japanese data, internal malignancies were more widely distributed across organs compared to the location-specific patterns observed in Chanda's Caucasian data.
• Specific associations noted: penile/scrotal/groin EP with genitourinary cancers, vulvar EP with female genitourinary cancers, and perianal EP with digestive system cancers in Chanda's data.

Conclusions:

• The association between Extramammary Paget's disease and internal malignancy requires careful consideration.
• Japanese patients with EP may have a broader range of associated internal malignancies, necessitating a more comprehensive screening approach compared to Caucasian populations.