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MCP-1 Levels are Associated with Cardiac Remodeling but not with Resistant Hypertension

Alessandra Mileni Versuti Ritter1, Ana Paula Cabral de Faria1, Andrea Sabbatini1

  • 1Universidade Estadual de Campinas (UNICAMP), Campinas, SP - Brazil.

Arquivos Brasileiros De Cardiologia
|April 6, 2017
PubMed

Insights

Monocyte chemoattractant protein-1 (MCP-1) levels did not differ between resistant hypertension and mild-to-moderate hypertension. However, lower MCP-1 levels were found in hypertensive patients with left ventricular hypertrophy (LVH).

Area of Science:

  • Cardiovascular Science
  • Inflammation Research
  • Hypertension Studies

Background:

  • Hypertension involves chronic inflammation, cytokine release, and target organ damage.
  • Monocyte chemoattractant protein-1 (MCP-1) dysregulation is linked to hypertension and cardiovascular issues, but mechanisms remain unclear.

Purpose of the Study:

  • To compare MCP-1 levels in resistant hypertension (RH) versus mild-to-moderate hypertension (HTN).
  • To investigate the association between MCP-1 levels and left ventricular hypertrophy (LVH) in hypertensive patients.

Main Methods:

  • Enrolled 256 hypertensive subjects (120 RH, 136 HTN).
  • Assessed plasma MCP-1 levels via ELISA and LVH via echocardiography.
  • Analyzed relationships between MCP-1, blood pressure, biochemical/hematologic profiles, and cardiac damage.

Main Results:

  • No significant difference in MCP-1 levels between RH and HTN groups.
  • Lower MCP-1 levels observed in hypertensive patients with LVH compared to those without.
  • Logistic regression confirmed MCP-1's independent association with LVH in the overall hypertensive population.

Conclusions:

  • MCP-1 levels are similar in RH and HTN, but decrease in hypertensive patients with LVH.
  • Suggests potential MCP-1 downregulation in hypertensive individuals with LVH, irrespective of hypertension severity.
Abstract

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