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Pancreas and Not Gut Mediates the GLP-1-Induced Glucoincretin Effect
Joel F Habener1, Violeta Stanojevic1
1Laboratory of Molecular Endocrinology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Cell Metabolism
|April 6, 2017
Abstract:
The gut is believed to be the source of GLP-1 that augments insulin secretion in response to oral nutrients. In this issue of Cell Metabolism, Chambers et al. (2017) shift the paradigm by finding that GLP-1 produced within the islets of the pancreas, and not the gut, is responsible for the incretin effect in mice.