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Related Experiment Videos

Modulating birth weight heritability in mice.

N Formoso-Rafferty, I Cervantes, N Ibáñez-Escriche

    Journal of Animal Science
    |April 6, 2017
    PubMed
    Summary

    Heritability of mouse birth weight can be modified by selecting for reduced residual variance or by managing environmental factors. This study explored heritability changes across generations in a divergent selection experiment.

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    Area of Science:

    • Animal Genetics
    • Quantitative Genetics
    • Animal Breeding

    Background:

    • Heritability estimates can vary based on models accounting for environmental factors.
    • Residual variance modification for birth weight is achievable through artificial selection, as demonstrated in mice.

    Purpose of the Study:

    • To estimate the evolution of birth weight heritability in mice during a divergent selection experiment.
    • To determine how heritability of birth weight differs across various systematic (environmental) effects.

    Main Methods:

    • Analysis of 15,431 birth weight records and 14,786 pedigree records from eleven generations of mice.
    • Utilized a model with heterogeneous residual variance, incorporating generation, litter size, sex, and parity number as systematic effects.

    Main Results:

    • Heritability differences between selected lines reached 0.06 in later generations.
    • Birth weight heritability varied from 0.04 to 0.22 when considering extreme systematic effects.

    Conclusions:

    • Heritability for mouse birth weight can be modulated by selecting for decreased residual variability.
    • Environmental management, specifically adjusting systematic effects, offers another avenue to influence birth weight heritability.

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