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Related Experiment Videos

Allergen-specific immunoglobulin E and allergic rhinitis severity.

Angelo G Corsico, Mara De Amici, Vanessa Ronzoni

    Allergy & Rhinology (Providence, R.I.)
    |April 7, 2017
    PubMed
    Summary

    Serum allergen-specific immunoglobulin E (sIgE) levels correlate with symptom severity in allergic rhinitis (AR) patients. This finding may help identify relevant biomarkers for AR, particularly for those considering immunotherapy.

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    Area of Science:

    • Immunology
    • Allergology
    • Clinical Medicine

    Background:

    • Allergic rhinitis (AR) is a prevalent condition diagnosed by correlating allergy sensitization with patient history.
    • Serum allergen-specific immunoglobulin E (sIgE) testing identifies relevant sensitizing allergens.
    • The Allergic Rhinitis and its Impact on Asthma (ARIA) classification categorizes AR by symptom severity and duration, though sIgE levels' relation to severity remains debated.

    Purpose of the Study:

    • To investigate the relationship between serum allergen-specific immunoglobulin E (sIgE) levels and symptom severity in patients diagnosed with allergic rhinitis (AR).
    • To assess the utility of sIgE levels as a biomarker for symptom severity in AR, guided by the ARIA classification.

    Main Methods:

    • A cohort of 217 AR patients (123 female, median age 39.5 years) was studied.

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  • House-dust mite-specific IgE (sIgE) levels were quantified using fluorescence enzyme immunoassay in peripheral blood.
  • Symptom severity was evaluated using the established ARIA classification criteria.

    • Main Results:

    • Significant differences in sIgE levels were observed across various AR symptom severity and duration groups.
    • Specifically, differences were noted between mild intermittent and mild persistent (p < 0.05), mild intermittent and moderate-to-severe persistent (p < 0.001), moderate-to-severe intermittent and moderate-to-severe persistent (p < 0.01), and mild persistent and moderate-to-severe persistent (p < 0.05) symptom categories.

    Conclusions:

    • Serum sIgE levels to house-dust mite appear to be a reliable biomarker for assessing symptom severity in allergic rhinitis (AR).
    • These findings hold potential clinical significance, especially for patients undergoing or considering allergen immunotherapy.