Traversing the RNA world.

Area of Science:

• Molecular Biology
• Genetics
• Biochemistry

Background:

• The author reflects on a career spanning five decades in RNA biology.
• The article discusses the author's personal experiences and views on science.
• It touches upon the challenges and rewards of scientific research, particularly in Eastern Europe during the 1960s and 1970s.

Purpose of the Study:

• To provide a personal account of a career in RNA biology.
• To share insights and advice for young researchers.
• To recount key research experiences and collaborations.

Main Methods:

• Personal narrative and reflection.
• Summary of research on transcription, translation, RNA splicing, ribosome biogenesis, and non-coding RNAs.
• Anecdotal accounts of collaborations and scientific competition.

Main Results:

• The author's research journey in RNA biology has been marked by fortunate discoveries and lucky escapes.
• Collaboration with rivals is presented as a successful strategy to mitigate competition.
• Significant advancements in understanding RNA biology, including regulatory non-coding RNAs, have occurred over the past fifty years.

Conclusions:

• A career in science, particularly RNA biology, offers numerous opportunities for discovery and personal growth.
• Collaboration and a positive approach to competition are beneficial for researchers.
• The author expresses gratitude for the scientific journey and the people encountered.