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Opiate receptor-mediated decrease in renal nerve activity during hypotensive hemorrhage in conscious rabbits.

H Morita1, Y Nishida, H Motochigawa

  • 1Department of Physiology, Kagawa Medical School, Japan.

Circulation Research
|July 1, 1988
PubMed
Summary
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Hemorrhage increases renal nerve activity, which naloxone (an opiate receptor blocker) reverses, restoring blood pressure and nerve activity. Naloxone also blocks opiate peptide effects on blood pressure and renal nerves.

Area of Science:

  • Physiology
  • Pharmacology

Background:

  • Hemorrhage significantly impacts renal nerve activity and arterial pressure.
  • Opiate receptors play a role in cardiovascular regulation during stress.

Purpose of the Study:

  • To investigate the effects of hemorrhage on renal nerve activity.
  • To examine the role of opiate receptor blockade with naloxone in modulating these responses.
  • To assess the influence of naloxone on opiate peptide-induced cardiovascular changes.

Main Methods:

  • Conscious rabbits were subjected to controlled hemorrhage.
  • Renal nerve activity and mean arterial pressure were continuously monitored.
  • Naloxone was administered intravenously to assess its effects.
  • Phenylephrine was used to counteract hypotension.

Related Experiment Videos

  • Methionine-enkephalin was administered to study opiate peptide effects.

    • Main Results:

    • Hemorrhage initially increased renal nerve activity, followed by a decrease during severe hypotension.
    • Naloxone administration restored mean arterial pressure and significantly increased renal nerve activity.
    • Phenylephrine partially restored renal nerve activity during hypotension.
    • Naloxone effectively blocked the depressor and renal nerve activity-reducing effects of methionine-enkephalin.

    Conclusions:

    • Opiate receptor blockade with naloxone can reverse the detrimental effects of hemorrhage on renal nerve activity and arterial pressure.
    • Naloxone plays a crucial role in modulating the cardiovascular response to hemorrhage and opiate peptides.
    • These findings highlight the involvement of endogenous opiates in cardiovascular regulation during stress.