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Related Experiment Videos

Abnormal scintigraphic evolution in AA hepatic amyloidosis.

F Lomeña1, R Roselló, F Pons

  • 1Nuclear Medicine Service, Hospital Clinic, Barcelona, Spain.

Clinical Nuclear Medicine
|March 1, 1988
PubMed
Summary

AA amyloidosis patients may show liver uptake of Tc-99m MDP bone imaging agents. This uptake resolved spontaneously, suggesting mechanisms beyond calcium binding in systemic amyloidosis.

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Area of Science:

  • Nuclear medicine
  • Rheumatology
  • Pathology

Background:

  • AA amyloidosis is a complication of chronic inflammatory conditions like ankylosing spondylitis.
  • Systemic amyloid deposition can affect various organs, including the liver.
  • Bone imaging agents like Tc-99m MDP are typically used for skeletal assessment.

Observation:

  • A patient with AA amyloidosis and ankylosing spondylitis exhibited intense liver uptake on Tc-99m MDP bone scans.
  • Liver biopsy confirmed hepatic amyloid deposition.
  • A follow-up bone scan one year later showed resolved liver uptake, despite unchanged clinical status.

Findings:

  • Tc-99m MDP demonstrates extraosseous uptake in hepatic amyloidosis.
  • The resolution of uptake suggests a dynamic process or a mechanism independent of simple calcium binding.

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  • This finding challenges the conventional understanding of Tc-99m MDP biodistribution in amyloidosis.

    • Implications:

    • Suggests a potential role for bone scintigraphy in monitoring amyloid deposition or related processes.
    • Highlights the need to investigate novel mechanisms for pyrophosphate and diphosphonate uptake in systemic amyloidosis.
    • May influence the interpretation of bone scans in patients with inflammatory diseases and suspected amyloidosis.