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Theranostic DNAzymes.

Wenhu Zhou1, Jinsong Ding2, Juewen Liu1

  • 1Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China, 410013.; Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario, Canada, N2L 3G1.

Theranostics
|April 7, 2017
PubMed
Summary
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DNAzymes, catalytic DNA molecules, offer dual therapeutic and diagnostic capabilities. This review highlights their progress in treating diseases and diagnosing conditions, paving the way for advanced theranostic applications.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Biotechnology

Background:

  • DNAzymes are catalytically active DNA molecules selected through in vitro methods.
  • RNA-cleaving DNAzymes are notable for their programmability, stability, and activity.
  • DNAzymes can be engineered for gene expression regulation and analyte detection.

Purpose of the Study:

  • To review the advancements in DNAzyme technology for theranostic applications.
  • To summarize DNAzyme applications in RNA cleavage for therapeutic purposes.
  • To outline the use of DNAzymes in disease diagnosis and theranostic strategies.

Main Methods:

  • In vitro selection for DNAzyme generation.
  • Review of literature on DNAzyme applications in RNA cleavage and analyte sensing.
Keywords:
DNAzymesRNAbiosensorsdelivery.metal ions

Related Experiment Videos

  • Analysis of theranostic DNAzyme strategies and challenges.

    • Main Results:

    • DNAzymes have shown potential in treating diseases like cancer and viral infections, with some formulations in clinical trials.
    • DNAzymes are effective in detecting various analytes, including metal ions and nucleic acids, for diagnostic purposes.
    • Theranostic DNAzymes integrate therapeutic and diagnostic functions, offering a promising approach for personalized medicine.

    Conclusions:

    • DNAzymes represent a versatile platform for both therapeutic interventions and diagnostic tools.
    • Overcoming challenges like in vivo activity, delivery, and quantification is crucial for clinical translation.
    • Future research directions include enhancing DNAzyme performance and exploring novel theranostic applications.