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CADASIL: two new cases with intracerebral hemorrhage
Chen Zhang1, Wei Li1, Shaowu Li2
1Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China.
Annals of Clinical and Translational Neurology
|April 7, 2017
Summary
Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) may be a risk factor for intracerebral hemorrhage (ICH). This study suggests CADASIL vasculopathy can cause ICH and may reduce edema around the hemorrhage.
Area of Science:
- Neurology
- Vascular Neurology
- Neuroimaging
Background:
- Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare genetic disorder affecting small blood vessels in the brain.
- The association between CADASIL and spontaneous intracerebral hemorrhage (ICH) is not well-established.
- Understanding CADASIL's role in ICH is crucial for diagnosis and patient management.
Purpose of the Study:
- To investigate whether CADASIL is a risk factor for spontaneous intracerebral hemorrhage (ICH).
- To explore the influence of CADASIL on the outcomes of ICH.
- To present cases illustrating the presentation of cerebral hemorrhages in CADASIL patients.
Main Methods:
- Case report of two patients with CADASIL presenting with cerebral hemorrhages.
- Clinical and neuroimaging data analysis.
- Review of literature on CADASIL and ICH.
Main Results:
- The reported cases suggest CADASIL vasculopathy can lead to ICH, even with minimal traditional vascular risk factors.
- Neuroimaging abnormalities were prominent in the affected individuals.
- A notable finding was decreased perihematomal edema in ICH patients with CADASIL.
Conclusions:
- CADASIL should be considered a potential risk factor for spontaneous intracerebral hemorrhage.
- CADASIL-related vasculopathy appears to be a significant factor in ICH development.
- The observation of reduced perihematomal edema warrants further investigation in larger cohorts.